Epigenetic mechanisms mediated by Retrotrasposons

Abstract

Preliminary Results

Cell identity is not a fixed state in space and time; rather, it is dynamic and multifaceted, constantly adapting to environmental stimuli. Epigenetics plays a fundamental role in enabling cells to respond to these changes, allowing them to reach a new state of balance or internal homeostasis. Studying epigenetic mechanisms involves unraveling a complex interplay of DNA sequences, RNA molecules, and proteins, which are intricately organized within chromatin in a highly structured nuclear topology to regulate gene expression. A comprehensive understanding of these regulatory networks must integrate Retrotransposable Elements (REs) which make up nearly half of the human genome and are pervasively transcribed, yet often overlooked. Our research has revealed that REs play a pivotal role in shaping gene expression and regulating T lymphocyte function under physiological conditions, within the tumor microenvironment, and throughout the human lifespan. Our mission is to fully elucidate the epigenetic mechanisms by which RE-transcripts regulate immune responses in both health and disease. By leveraging a broad spectrum of cutting-edge omics technologies, advanced computational tools, high-resolution imaging approaches, and functional assays, our lab is dedicated to deciphering the epigenetic role of REs in immune regulation. Given our expertise in this area, our lab is an active member of the FANTOM_6 consortium.