IRescue: uncertainty-aware quantification of transposable elements expression at single cell level

Estimating RE expression in scRNA-seq poses significant computational challenges due to multi-mapping reads aligning to interspersed repeats. To address this limitation, we developed IRescue. IRescue adapts a gold-standard UMI-deduplication strategy to correct sequencing errors and remove PCR duplicates along with an Expectation-Maximization algorithm to probabilistically redistribute multi-mapping reads, enhancing the accuracy of RE expression estimates.

Meet us at the European Human Genetics Conference 2025!

The program will provide educational sessions, symposia of selected abstracts, invited speakers and posters about the latest advancements in in basic and applied human and medical genetics. Our researchers will show our latest data about the involvement of RE in immunity and cancer immunology, you do not want to miss it!

See you there!

Meet us at the 2025 Annual Congress of the European Association for Cancer Research!

It will be a four day congress dedicated to basic, preclinical and translational cancer research across a wide breadth of topics. Our researchers will show our latest data about the involvement of RE in cancer immunology, you do not want to miss it!

See you there!