Genome Biology lab

At the Genome Biology Lab, we delve into the understanding of the molecular function of expressed Retrotransposable Elements (REs), challenging the notion of these sequences as merely selfish DNA within the human genome. Our research reveals that RE RNAs are intricately connected to fundamental cellular processes. Indeed, transcripts derived from or containing REs exhibit cell type-specific expression patterns indicating their involvement in specialized cellular functions. With this regard we have thoroughly demonstrated a pivotal role for REs in governing T cell function —not only under normal physiological conditions but also within the tumor microenvironment and across the human lifespan.

Much like traditional genes, REs are responsive to signaling pathways, transcription factors, and epigenetic and splicing modifiers, suggesting their active participation in gene regulatory networks. Our core aspiration is to prove that REs can serve as catalysts within these networks, influencing gene expression and T cell behavior. To this aim the lab combines molecular, genomic and advanced imaging approaches with computational biology to describe the molecular mechanisms of DNA repetitive sequences in human biology. Through our exploration of these ‘dark’ regions of the genome, we aim to uncover the hidden regulatory potentials of REs and their implications for human health and disease.